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The ADC linker connects antibodies to payloads in antibody-drug conjugates (ADCs). Its chemical and physicochemical properties affect ADC potency, in vivo stability, and tolerability. The ADC linkers are mostly classified into two categories: cleavable (such as pH-sensitive linkers, disulfide linker) and noncleavable.

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Ioannis Skiotes Before falling mentally ill with Manic Depression at 25 years old, I was a two time college graduate, physically fit, healthy in all regards. The wicked two year mentally ill journey that I embarked upon profoundly changed my life. The pivotal point was terminated from my first professional position out of college with Burroughs Corporation in Tampa, FL. Feeling lost, alone, I sunk into severe depression, wandered the highways aimlessly. Nearly jumped off a bridge in Tallahassee, but too scared to commit suicide. Felt my mental condition severely slipping. The finality was hearing a humming noise like a tuning fork. Eventually wound up at my brother’s in the hometown of Joliet, IL, where I heard voices. Without health insurance, went to Manteno State Mental Institution. Same place as my mother, near the same age, with the same illness, with the same length of stay – one year. Theories that link genetics to mental illness may have a point.

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